3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 5-cyanopyridin-3-ylboronate
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile
CAS: 402718-29-0
Molecular Formula: C12H15BN2O2
3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 5-cyanopyridin-3-ylboronate - Names and Identifiers
3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 5-cyanopyridin-3-ylboronate - Physico-chemical Properties
| Molecular Formula | C12H15BN2O2 |
| Molar Mass | 230.07 |
| Density | 1.107g/cm3 |
| Melting Point | 122-124℃ |
| Boling Point | 352.638°C at 760 mmHg |
| Flash Point | 167.07°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.507 |
3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 5-cyanopyridin-3-ylboronate - Introduction
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile is an organic compound with the chemical formula C12H17BN2O2.
Nature:
-Appearance: It is white to light yellow powder or crystal.
-Solubility: Soluble in alcohol, ester and ketone, slightly soluble in ether and chloroform, insoluble in water.
Use:
-As a catalyst: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile can be used as an effective catalyst in organic synthesis for hydrogenation reactions, cross-coupling reactions and aromatic hydrocarbon functionalization reactions.
-Preparation of organometallic compounds: It can also be used to prepare organometallic-containing compounds, such as pyridine-boronic acid pinacol complexes.
Preparation Method:
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile can be prepared by the following two-step reaction:
1. 3-Cyanopyridine is reacted with a tertiary nitrile in the presence of stannous chloride to produce 5-(3-{[(trimethylstannanyl)oxy]carbonyl}phenyl)pyridine (intermediate) having a tertiary nitrile group.
2. reacting the intermediate with dimethyl brominated boronic acid to finally obtain 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile.
Safety Information:
- 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile specific safety information may vary depending on the supplier or preparation method, so you should check the safety data sheet provided by the relevant supplier before use.
-When using, avoid contact with skin and eyes, and make sure to operate in a well-ventilated place.
-Keep dry, fire-proof and free from oxidizers during storage and handling.
-If ingested by mistake or discomfort due to inhalation, seek medical advice immediately.
Nature:
-Appearance: It is white to light yellow powder or crystal.
-Solubility: Soluble in alcohol, ester and ketone, slightly soluble in ether and chloroform, insoluble in water.
Use:
-As a catalyst: 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile can be used as an effective catalyst in organic synthesis for hydrogenation reactions, cross-coupling reactions and aromatic hydrocarbon functionalization reactions.
-Preparation of organometallic compounds: It can also be used to prepare organometallic-containing compounds, such as pyridine-boronic acid pinacol complexes.
Preparation Method:
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile can be prepared by the following two-step reaction:
1. 3-Cyanopyridine is reacted with a tertiary nitrile in the presence of stannous chloride to produce 5-(3-{[(trimethylstannanyl)oxy]carbonyl}phenyl)pyridine (intermediate) having a tertiary nitrile group.
2. reacting the intermediate with dimethyl brominated boronic acid to finally obtain 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile.
Safety Information:
- 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carbonitrile specific safety information may vary depending on the supplier or preparation method, so you should check the safety data sheet provided by the relevant supplier before use.
-When using, avoid contact with skin and eyes, and make sure to operate in a well-ventilated place.
-Keep dry, fire-proof and free from oxidizers during storage and handling.
-If ingested by mistake or discomfort due to inhalation, seek medical advice immediately.
Last Update：2024-04-10 22:29:15
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Product Name: 3-Cyano-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-yl)Pyridine Visit Supplier Webpage Request for quotation
CAS: 402718-29-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 402718-29-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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